The Tumor Necrosis Factor (TNF) Superfamily of proteins represents one of the most biologically influential groups of cytokines in immunology and cell biology. Characterized by their shared structural motifs and receptor-interacting domains, these proteins orchestrate a wide spectrum of cellular processes—ranging from immune cell activation and survival to programmed cell death. Their...
In the post-genomic era, understanding how proteins interact in dynamic networks has become a central theme in biomedical research. Protein pathway profiling offers a high-resolution approach to dissecting cellular signaling cascades by identifying changes in protein expression, phosphorylation status, interaction dynamics, and pathway-specific activation. This strategy enables researchers to...
In modern biosciences, uncovering the evolutionary background of biological molecules is crucial for understanding their functions and relationships. Protein phylogenetic analysis is a widely used strategy that interprets evolutionary patterns by studying protein sequences across species. It provides essential insights into molecular function, evolutionary divergence, and species development....
The Kinesins Gene Family is a critical group of motor proteins responsible for a wide array of cellular processes, ranging from intracellular transport to mitotic spindle assembly. These ATP-dependent molecular motors move along microtubules and are essential for proper cell division, neuronal function, and organelle positioning. Understanding kinesin family structure, regulation, and...
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