Andrew Tate is a British former kickboxer, mixed martial artist, and entrepreneur. He was born on December 1, 1986, in Washington, England. Tate is best known for his successful kickboxing career, during which he won multiple world championships in various weight classes. He retired from kickboxing in 2017 to focus on his business ventures and online presence. In addition to his athletic career, Tate is also known for his controversial statements and views, particularly regarding gender and race. He has been criticized for promoting misogynistic and racist views, including advocating for the legalization of rape, and for his involvement in far-right groups and organizations. Tate has also been involved in various business ventures, including the creation of a digital marketing agency and the development of several mobile apps. Overall, Andrew Tate's career has been marked by both success in sports and controversy surrounding his views and statements.

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Kari Lake is an American journalist and news anchor who worked for the Fox 10 Phoenix news station in Arizona for over 20 years. She was born on September 10, 1968, in Illinois, USA. Lake started her career in journalism as a news reporter and anchor in Michigan before moving to Arizona in 1994 to join Fox 10 Phoenix. During her time at the station, she covered a range of news stories, including breaking news, crime, and politics. She also hosted the station's popular morning show, "Fox 10 Arizona Morning." In 2021, Lake resigned from Fox 10 Phoenix, citing concerns about the direction of journalism and media. She later announced her candidacy for governor of Arizona in the 2022 election as a Republican. Lake's decision to enter politics has sparked controversy and criticism, with some accusing her of promoting conspiracy theories and aligning herself with far-right groups. However, Lake has defended her views and platform, emphasizing her commitment to traditional conservative values and her opposition to what she sees as excessive government regulation and censorship of free speech.

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Being regulated by LH and FSH, in order for these hormones to be released the pituitary gland must first be stimulated in order to achieve this purpose; once achieved and LH and FSH are released, testicular stimulation is achieved thereby causing the production of testosterone. As you can easily see, as important as the testicles are in testosterone production, the pituitary gland is of equal importance; without adequate pituitary function natural testosterone production cannot occur. The Organon group in the Netherlands were the first to isolate the hormone, identified in a May 1935 paper "On Crystalline Male Hormone from Testicles (Testosterone)". They named the hormone testosterone, from the stems of testicle and sterol, and the suffix of ketone. The structure was worked out by Schering's Adolf Butenandt, at the Chemisches Institut of Technical University in Gda艅sk The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch. Only a week later, the Ciba group in Zurich, Leopold Ruzicka (1887鈥?976) and A. Wettstein, published their synthesis of testosterone.These independent partial syntheses of testosterone from a cholesterol base earned both Butenandt and Ruzicka the joint 1939 Nobel Prize in Chemistry.Testosterone was identified as 17尾-hydroxyandrost-4-en-3-one (C19H28O2), a solid polycyclic alcohol with a hydroxyl group at the 17th carbon atom. This also made it obvious that additional modifications on the synthesized testosterone could be made, i.e., esterification and alkylation. Testosterone is observed in most vertebrates. Testosterone and the classical nuclear androgen receptor first appeared in gnathostomes (jawed vertebrates). Agnathans (jawless vertebrates) such as lampreys don't produce testosterone but instead use androstenedione as a male sex hormone. Fish make a slightly different form called 11-ketotestosterone.Its counterpart in insects is ecdysone.The presence of these ubiquitous steroids in a wide range of animals suggest that sex hormones have an ancient evolutionary history. 2. How Does Raw Testosterone powder Works? The effects of testosterone in humans and other vertebrates occur by way of multiple mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.Androgens such as testosterone have also been found to bind to and activate membrane androgen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5伪-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5伪-reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[149] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Androgen receptors occur in many different vertebrate body system tissues, and both males and females respond similarly to similar levels. Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a share of biological differences between males and females. The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol. In the bones, estradiol accelerates ossification of cartilage into bone, leading to closure of the epiphyses and conclusion of growth. In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus (especially affecting LH secretion). In many mammals, prenatal or perinatal "masculinization" of the sexually dimorphic areas of the brain by estradiol derived from testosterone programs later male sexual behavior. 3. How to Use Raw Testosterone powder? Testosterone is used as a medication for the treatment of males with too little or no natural testosterone production, certain forms of breast cancer,and gender dysphoria in transgender men. This is known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), which maintains serum testosterone levels in the normal range. Decline of testosterone production with age has led to interest in androgen replacement therapy.It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful. Testosterone is the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.In addition, testosterone is involved in health and well-being, and the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss. Testosterone is also used as a medication to treat male hypogonadism and certain types of breast cancer.Since testosterone levels gradually decrease as men age, synthetic testosterone is sometimes prescribed to older men to counteract this deficiency. Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. It exerts its action through binding to and activation of the androgen receptor. In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. On average, in adult males, levels of testosterone are about 7鈥? times as great as in adult females. As the metabolic consumption of testosterone in males is greater, the daily production is about 20 times greater in men. Females are also more sensitive to the hormone. 4. Dosage of Raw Testosterone powder Testosterone is a male sex hormone that is important for sexual and reproductive development. The National Institutes of Health regards testosterone as the most important male hormone. Women also produce testosterone, but at lower levels than men. Testosterone belongs to a class of male hormones called androgens, which are sometimes called steroids or anabolic steroids. In men, testosterone is produced mainly in the testes, with a small amount made in the adrenal glands. The brain's hypothalamus and pituitary gland control testosterone production. The hypothalamus instructs the pituitary gland on how much testosterone to produce, and the pituitary gland passes the message on to the testes. These communications happen through chemicals and hormones in the bloodstream. Testosterone injections deliver testosterone into the muscle. The testosterone is then absorbed directly into the blood stream over time. The absorption period depends on the type of testosterone injected. Injections usually take place in the thighs, glutes or deltoid muscles. The most common forms of injectable testosterone for testosterone replacement therapy (TRT) include testosterone enanthate (TE) and testosterone cypionate (TC). Testosterone enanthate and testosterone cypionate are modified forms of testosterone. Specifically, a carboxylic acid ester has been added to the 17-beta hydroxyl group. This attachment makes TE and TC less polar than free T. As a result, they have longer half-lives and are absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed to yield free (active) T. Due to their long half-lives, both TE and TC provide a sustained release of testosterone into the bloodstream for one to two weeks. As a result, testosterone injections of TE or TC need only be administered every week or every other week. Dosing regimens for TRT, the recommended dosing regimen of testosterone enanthate or testosterone cypionate for testosterone therapy is 75 to 100 mg every week or 150 to 200 mg every other week.1-5 Weekly injections are preferred because more frequent injections lower fluctuations in serum testosterone. About 30% of men treated for low testosterone use testosterone injections. [About 65% of men use testosterone gel. 5. Warning of Raw Testosterone powder You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: diabetes; enlarged prostate; heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby or cause birth defects. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. 6. What Are the Possible Side Effects of Raw Testosterone powder? The safety of testosterone treatment is still being researched. It has several possible side effects and some possible long-term effects, as well. For example, testosterone treatment lowers sperm count, so Michael A. Werner, a specialist in andropause, or "male menopause," recommends that men who desire future fertility avoid testosterone treatments. Other side effects include increased risk of heart problems in older men with poor mobility, according to a 2009 study at Boston Medical Center. A 2017 study published in JAMA found that treatments increase coronary artery plaque volume. Additionally, the Food and Drug Administration (FDA) requires manufactures to include a notice on the labeling that states taking testosterone treatments can lead to possible increased risk of heart attacks and strokes. The FDA recommends that patients using testosterone should seek medical attention right away if they have these symptoms: Chest pain Shortness of breath or trouble breathing Weakness in one part or one side of the body Slurred speech The treatment can also increase the risk of sleep apnea, promote prostate and breast growth, and even encourage the development of prostate cancer, according to the Mayo Clinic. Call your doctor at once if you have: nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs; high levels of calcium in the blood--stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or liver problems - upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). 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Report: Elon Musk plans to cut 75% of Twitter workforce Twitter’s workforce is likely to be hit with massive cuts in the coming months, no matter who owns the company, interviews and documents obtained by The Washington Post show, a change likely to have major impact on its ability to control harmful content and prevent data security crises. Elon Musk told prospective investors in his deal to buy the company that he planned to get rid of nearly 75 percent of Twitter’s 7,500 workers, whittling the company down to a skeleton staff of just over 2,000. Even if Musk’s Twitter deal falls through — and there’s little indication now that it will — big cuts are expected: Twitter’s current management planned to pare the company’s payroll by about $800 million by the end of next year, a number that would mean the departure of nearly a quarter of the workforce, according to corporate documents and interviews with people familiar with the company’s deliberations. The company also planned to make major cuts to its infrastructure, including data centers that keep the site functioning for more than 200 million users that log on each day. The extent of the cuts, which have not been previously reported, help explain why Twitter officials were eager to sell to Musk: Musk’s $44 billion bid, though hostile, is a golden ticket for the struggling company — potentially helping its leadership avoid painful announcements that would have demoralized the staff and possibly crippled the service’s ability to combat misinformation, hate speech and spam. The impact of such layoffs would likely be immediately felt by millions of users, said Edwin Chen, a data scientist formerly in charge of Twitter’s spam and health metrics and now CEO of the content-moderation start-up Surge AI. He said that while he believed Twitter was overstaffed, the cuts Musk proposed were “unimaginable” and would put Twitter’s users at risk of hacks and exposure to offensive material such as child pornography. “It would be a cascading effect,” he said, “where you’d have services going down and the people remaining not having the institutional knowledge to get them back up, and being completely demoralized and wanting to leave themselves.” On Thursday evening, Twitter’s top lawyer Sean Edgett sent out a note to all employees saying the company did not have any confirmation from Musk about his plans. Twitter’s own, smaller-scale “cost savings discussions” were put on hold once the merger agreement was signed, Edgett said, according to an email viewed by The Post. In internal Slack groups, Twitter employees reacted to the news with anger and resignation, supporting each other and making jokes about the turmoil of the past few months, according to people familiar with the conversations. Twitter and Musk are expected to close the purchase by Oct. 28. Planning for the closing is moving forward in apparent good faith after months of legal battles, say people familiar with the negotiations who spoke on the condition of anonymity to discuss internal deliberations. If the deal closes, Musk would immediately become Twitter’s new owner. Twitter did not immediately respond to request for comment. “The easy part for Musk was buying Twitter and the hard part is fixing it,” said Dan Ives, a financial analyst with Wedbush Securities. “It will be a herculean challenge to turn this around.” Nell Minow, a corporate governance expert who is vice chair of ValueEdge Advisors, said Musk was likely shopping ambitious plans to potential investors but will face challenges in implementing his proposals. “He’s got to be able to show if he makes those cuts, what happens next?” she said. “What’s he gonna replace it with, AI?” Company executives have repeatedly told employees that there are no immediate layoff plans during town hall meetings. In the one town hall that he attended, in June, Musk was pointedly asked a question about layoffs. He answered that he didn’t see a reason low performers should remain employed. But the new details, which reflect conversations over the last few months, highlight the extreme nature of Musk’s planned transformation of Twitter amid the challenge of making the long struggling company more profitable. Twitter has never achieved the profit margins or size of other social sites like Meta and Snap. And Musk’s plan to take the company private — freeing it from having to please Wall Street — was a key reason former CEO and co-founder Jack Dorsey got behind Musk’s bid. Musk and his representatives did not respond to requests for comment. The months-long roller-coaster saga of Musk’s on-again off-again bid for ownership — coupled with a tense legal battle — has left Twitter battered and bruised. It faces significant worker attrition, slowed hiring, stalled projects and a volatile stock price. Recently Andrea Walne, a general partner at Manhattan Venture Partners, a firm that has invested in the deal, told Business Insider that she thinks Twitter is worth only $10 billion to $12 billion and that other partners were trying to get out. Musk himself said that he and his investors were “obviously overpaying” for the site during Tesla’s earnings call on Wednesday. Walne did not respond to requests for comment. Musk has suggested he’ll loosen content moderation standards and favors restoring former president Donald Trump’s account (on Tuesday he posted a meme of himself, Kanye West and Trump each holding a sword for the social media company he owns or is in the process of purchasing). Musk has told investors that he plans to double revenue in three years, and would triple the number of daily users that can view ads in the same period, though he’s offered scant details on how he would accomplish those goals. Twitter estimates that its monetizable daily active users (MDAU), defined as the number of users eligible to see ads, is 237.8 million, up 16.6 percent compared with the same quarter last year. But documents that have emerged in Twitter’s court battle with Musk point to far lower numbers, with Musk’s side claiming, using Twitter’s own data, that fewer than 16 million users see the vast majority of ads. Moreover, the time those users spend browsing Twitter declined 10 percent over the course of 2021 and only recovered slightly in the first quarter of 2022, according to the interviews. Gutting and then reshaping the workforce through rehiring chosen people is a huge part of Musk’s ambitions, according to interviews and documents. Though Musk has previously indicated he would be open to cutting staff — legal filings show that he agreed with a friend over text that the company’s head count wasn’t justified by its revenue when compared with other tech companies — he has not offered specific numbers publicly. In presentations prepared for investors and other interested parties, Musk’s optimistic business projections were fueled in part by steep jobs cuts across what was termed a “bloated” organization. One prospective investor, who spoke on the condition of anonymity to candidly describe Musk’s proposals, likened them to leveraged buyouts, where companies are made profitable through devastating cuts to labor and operations. But Musk has told associates he thinks that dramatically slimming down the company is the first step to executing a turnaround strategy that would then involve bringing in more effective workers and profitable innovations. Those include expanding on new services that he has claimed could bring in more revenue, such as a subscription business where people pay to subscribe to exclusive content from powerful figures and influencers. (Twitter is currently experimenting with such a model, called Twitter Blue). But Twitter’s own data has found that subscriptions may not bring in significant new revenue, according to the interviews. That’s because the users who view the most ads — roughly the top 1 percent of users in the United States — are also the ones most likely to join a subscription service. If they began paying a monthly subscription and went ad-free, the program could cannibalize the most lucrative part of Twitter’s current ad business. Twitter’s budget for head count — roughly $1.5 billion last year — includes many highly paid ad salespeople and several thousand engineers. The company also spends hundreds of millions on contracting firms that pay people to review reports of hate speech, child sexual abuse, and other ugly and rule-breaking content on the internet. Twitter’s median compensation — the point at which half make more and half make less — is about $240,000 for all employees and $308,000 for engineers. Some of the planned cuts were put on hold pending the sale to Musk, which was announced in April. The company is instituting a performance review system called stack ranking that requires managers to grade employees on a numerical curve, so that a set percentage of workers will always be marked as low performers, according to one of the company documents obtained by The Post. The move has been protested by staff members, but Twitter says other tech companies have the same practices. Human resources staff at Twitter have told employees that they aren’t planning for mass layoffs, but documents show that extensive plans to push out staff and cut down on infrastructure costs were already in place before Musk offered to buy the company. Musk would then have built on those plans by first targeting low performers — people the company’s human resources system designated as “not on track” or receiving below a 3 out of 5 rating — before moving to other phases of downsizing. For weeks leading into the acquisition announcement, Musk and his attorney Alex Spiro pitched a who’s who crowd of elite investors in Silicon Valley and Wall Street on a deal that was billed as a chance not only to transform underperforming Twitter, but to work with the celebrated Musk. Not all potential investors received the same details from Musk’s team. Some of Musk’s biggest partners in the deal, including Oracle co-founder Larry Ellison and Sequoia partner Doug Leone were also Trump supporters and self-proclaimed believers in the type of free speech ideology Musk promised to bring back to the platform. (Leone is no longer a Trump supporter but is said to take an expansive view of free speech). Hedge fund manager Kenneth Griffin, the second largest GOP donor in the current midterm cycle, also committed a smaller amount — under $20 million compared with $1 billion from Ellison — to the deal, The Post has learned. But many potential notable funders passed. Private equity giants T. Rowe Price, TPG and Warburg Pincus, who collectively control more than $1.4 trillion, all decided not to invest after being approached by Musk’s representatives, according to people familiar with the process. And other prominent Silicon Valley heavyweights said no as well. LinkedIn founder Reid Hoffman helped connect Musk with Microsoft CEO Satya Nadella as part of the money-raising process, but decided not to invest himself, according to people familiar with the situation. Hoffman is a major Democratic donor, and Musk at the time was already talking about restoring Trump. Founders Fund, the Silicon Valley venture firm founded by billionaire Republican donor Peter Thiel, also said no. Thiel first worked with Musk in 2000 when the two merged their companies to form PayPal, and Thiel’s associates have said he is a fan of Musk running Twitter. It’s unclear whether these parties didn’t buy into Musk’s lofty projection, or didn’t want to be involved politically. Some passed after the company’s finances and Musk’s own predicament began to look less attractive. One person who lost interest told The Post that he was alarmed after the market downturn and the cost of the deal began taking a toll on Musk’s finances and the crown jewel of his portfolio, Tesla. It hasn’t helped that Musk relentlessly attacked Twitter and its leadership after announcing his takeover, pushing down its stock price. Musk’s latest turnabout only added to the sense of chaos. “[It’s] like you bought a new car, you decided you didn’t want it, and then you crash it,” the person said. “And then you’re like ‘I’ll keep it.’”